Damien Comolli has left his role as Liverpool`s director of football by mutual consent.
The Frenchman joined Liverpool as a director of football strategy in November 2010, with his role redefined in March last year.
During that time he has overseen a number of high-profile signings, including the club-record £35million acquisition of Andy Carroll from Newcastle, while he also survived a change of manager when Kenny Dalglish returned to the club to replace Roy Hodgson.
A club statement from principal owner John Henry read: "We are grateful for all of Damien's efforts on behalf of Liverpool and wish him all the best for the future."
Comolli himself, who has also worked for Arsenal and Tottenham, said: "I am grateful to have been given the opportunity to work at Liverpool and am happy to move on from the club and back to France for family reasons. I wish the club all the best for the future."
Dalglish said he had had a "fantastic" working relationship with Comolli.
The Anfield boss added: "He has been really helpful in every transfer target we've gone for. Everyone who has come into the club since Damien has been here was of my choice. Once I made the choice who I wanted Damien went away and did a fantastic job of bringing them in.
"It is sad to see anyone leave the football club and he goes with my best wishes and hopefully it is not long before we meet again. We wish him well with everything that he does."
In addition to the capture of Carroll, other signings to have headed to Anfield while Comolli has been in office include the likes of Luis Suarez, Jordan Henderson, Charlie Adam, Stewart Downing and Jose Enrique who, between them, purchased for a total touching £90million.
They have not all been universally popular additions to the Liverpool squad, though, with some fans questioning the merits of paying such high prices for players who have yet to make a consistent impact at Anfield.